Clinical Trials available

CHOP: Children's Hospital of Philadelphia is looking into the use of CBD for kids under 18 with autism. Please call and see if your child qualifies!

Feb 2019

Medical literature

Alzheimer's and Parkinson's

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Driving Impairment

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  Driving Impairment
Drug and Alcohol Crash Risk: A Case-Control Study
National Highway Traffic Safety Administration
Compton, et al, 2015 


  

Driving Impairment
Drug and Alcohol Crash Risk: A Case-Control Study
U.S. Department of Transportation
National Highway Traffic Safety Administration
Ramaekers et al, 2010 


 https://mashable.com/category/weed-wise/ 

More

Schizophrenia/Mania

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Am J Psychiatry. 2018 Mar 1;175(3):225-231. doi: 10.1176/appi.ajp.2017.17030325. Epub 2017 Dec 15.

Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial.


SSRI:  May increase episodes of mania 

Breast Cancer

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2017 - 

http://www.cannmedevents.com/wp-content/uploads/2017/05/Sean-McAllister-2017-02-28-CannMed-2017.pdf

2009 - Dr. Sean McAllister

https://beyondthc.com/wp-content/uploads/2018/12/CBD-for-Breast-Cancer-%E2%80%94McAllister-2009.pdf


2010 - Dr. Christina Sanchez: 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917429/

 Conclusion: cannabinoids inhibit cancer cell proliferation, induce cancer cell apoptosis, and impair tumor angiogenesis.

Cardiovascular

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Small Study but consistent with my results: 10 Men with 600 mg dose CBD = drop in BP ~6 pts, but increase in HR ~7 bpm. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470879/


Coumadin/Warfarin interactions:   

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789126/ 


 https://www.asra.com/asra-news/article/150/is-it-time-to-add-cannabinoids-to-the-as 

Protecting Patients

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Arizona and Boston have now had legal cases protecting a patient's right to use Cannabis products. March 2019 in Arizona a lawsuit was brought against Walmart for an employee who tested positive for THC. It is currently in favor of the patient!


 https://arizonacannabismonthly.com/federal-court-affirms-amma-patients-protection/  

Negative Side Effects

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Medication Interactions:

Warfarin: THC and CBD increase warfarin levels (Yamaori et al 2012). Frequent cannabis use has been

 Warfarin: THC and CBD increase warfarin levels (Yamaori et al 2012). Frequent cannabis use has been associated with increased INR. 

Alcohol: Alcohol may increase THC levels (Hartman 2015). 

Theophylline: Smoked cannabis can decrease theophylline levels (Stout and Cimino 2014).

Indinavir or nelfinavir: Smoked cannabis had no effect (Abrams et al 2003). 

Docetaxel or irinotecan: Cannabis infusion (tea) had no effect (Engels et al 2007).  

Clobazam: In children treated with CBD for epilepsy, CBD increased clobazam levels (Geffrey et al 2015)

SSRI:  May increase episodes of mania 

Site Content

Pancreatic Cancer

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 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352507/ 

Summary:  Cannabinol receptors have been identified in pancreatic cancer with several studies showing in vitro antiproliferative and proapoptotic effects. Their effects are predominately mediated through, CBR-1, CBR-2, and PR55 pathways. In vitro studies consistently demonstrated tumor growth-inhibiting effects with CBD, THC, and synthetic derivatives. Synergistic treatment effects have been shown in two studies with the combination of CBD/synthetic cannabinoid receptor ligands and chemotherapy in xenograft and genetically modified spontaneous pancreatic cancer models. There are no clinical studies showing treatment benefits in patients with pancreatic cancer. 


If you have pancreatic CA and are treating with cannabis - a new research project with Dr. Ana Jewitt at UCLA may be linked to a cure!

Glioblastoma

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 This data suggests that CBD may, via modulation of EVs and PHB, act as an adjunct to enhance treatment efficacy in GBM, supporting evidence for efficacy of cannabinoids in GBM. 

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314156/ 


 Preliminary Data shows double the life expectancy with Cannabis (sativex) + Temzolomide (TMZ) chemotherapy

S Short, C Little.  

Abstract Neuro-Oncology, Nov 2017

Poster SNO 2017

Cancer & Chemo Related Side Effects Treatment

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Starts in 1975: For chemo associated nausea/vomiting: https://www.ncbi.nlm.nih.gov/pubmed/1099449 

C Diff?

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 Cannabidiol improved Clostridium difficile toxin A-induced damage in Caco-2 cells, by inhibiting the apoptotic process and restoring the intestinal barrier integrity, through the involvement of the CB1 receptor. 

 https://journals.sagepub.com/doi/10.1177/2050640617698622 .

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Reputable reference websites

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UCSD CMCR, UCLA Cannabis Initiative, UC Berkely (coming soon)

Society of Cannabis Clinicians

Dr. Dustin Sulak

FAQs

coming soon